NatureAbstract_1

Peyronie’s Disease was described by Francois de la Peyronie, surgeon to Louis XIV of France, in 1743. It is a condition marked by penile curvature, indentation, and loss of penile length (with or without pain) upon erection. These deformities of the penis can appear in men of all ages but is most commonly present in men in their 50’s.

The cause of Peyronie’s Disease is not well understood. In most cases, the disease is a result of inflammation and plaque formation after repeated trauma to the penis; most commonly occurring during sexual intercourse.

The deformity of the penis is due to plaque formation that is, in fact, a thick inelastic scar. This thick inelastic scar can create curvature of the penis upwards, downwards or sideways.

Erectile dysfunction is also found to occur in up to 58% of men with Peyronie’s Disease 1.

 

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1. The Management of Peyronie’s Disease: Evidence-based 2010 Guidelines.
Ralph, D., Gonzalez-Cadavid, N., et al. J. Sex Med 2010; vol. 7